Symbol
Name
ID

Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Lymphadenopathy	Splenomegaly
Disease(s) Associated with XRCC5
multiple myeloma

Mouse Phenotypes

thymus hypoplasia

abnormal B cell differentiation

abnormal class switch recombination

arrested B cell differentiation

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-negative T cell number

arrested T cell differentiation

increased neutrophil cell number

increased dendritic cell number

decreased B-2 B cell number

increased B-1a cell number

increased B-1b cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

absent T cells

spleen hypoplasia

lymph node hypoplasia

abnormal humoral immune response

Availability

Mouse Genotype

Xrcc5^m1Btlr/Xrcc5^m1Btlr

Xrcc5^tm1Dbr/Xrcc5^tm1Dbr

Xrcc5^tm1Nus/Xrcc5^tm1Nus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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